Hepatoprotective Effects of Phyllanthus Amarus Ethanolic Extract On CCL4-Induced Hepatotoxicity in Wistar Rats

Abstract

The hepatoprotective effect of ethanolic leaf extracts from Phyllanthus amarus was studied in relation to CCl4-induced hepatotoxicity in wistar rats. As controls, animals from Group 1 were used. 3mL/kg body weight (bw) of 30% CCl₄ in olive oil was administered once per week for two weeks to Group 2 animals to harm their livers. Animals in Groups 3 and 4 were treated with Phyllanthus amarus ethanol leaf extracts (50 mg/kg and 70 mg/kg, respectively) following CCl₄ induction.. The 14-day trial was conducted. The results of this study indicate that, when compared to those who received CCl₄, those who received ethanol leaf extracts of phyllanthus amarus showed a comparatively considerable liver protection against CCl₄-induced damage. A significant increase (p<0.05)

in the levels of biochemical parameters: Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), Alkaline phosphatase (ALP) of rats administered with CCl₄ only was also observed. The phyllanthus amarus extract’s activity at 70mg/kg bw (higher dose) give a reasonable decrease in the amount of these liver enzymes. Deducing from study results, it indicates that Phyllanthus amarus leaf extracts could be an effective hepatoprotective agent in CCl₄ mediated liver toxicity in adult wistar rats and drug development.