International Journal of Scientific Research and Innovative Studies

The Prevalence and Trend of Metabolic Syndrome in Mediterranean Regions: A Comprehensive Review

Nessren Ahmad Alduboie et al. — 2024-12-01

Metabolic Syndrome (MetS) is a cluster of interconnected conditions that increase the risk of cardiovascular disease, type 2 diabetes mellitus, and other chronic illnesses. These conditions include central obesity, hypertension, dyslipidemia, and insulin resistance. Mediterranean regions exhibit unique dietary, genetic, and lifestyle patterns that influence the prevalence of MetS. This review examines recent studies assessing the prevalence, trends, and contributing factors of MetS in Mediterranean populations. Key findings highlight regional differences, impacts of dietary habits, and the importance of lifestyle interventions in managing MetS in these regions.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/285
https://doi.org/10.5281/zenodo.14510792

Health-Promoting Lifestyle and Its Related Factors in Pregnant Women: A Comprehensive Review

Komail Wasel Alamer et al. — 2024-12-01

Pregnancy is a critical period that requires women to adopt health-promoting behaviors to ensure optimal maternal and fetal health. A health-promoting lifestyle includes proper nutrition, regular physical activity, stress management, and adequate prenatal care. Various factors, such as socioeconomic status, education level, social support, and access to healthcare, influence the adoption of such behaviors. This review examines the components of a health-promoting lifestyle during pregnancy, the factors influencing these behaviors, and the implications for improving maternal and neonatal outcomes.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/275
https://doi.org/10.5281/zenodo.14480785

Treatment in Severe Acute Pancreatitis – Still a Reason for Debate: A Comprehensive Review

Mohammed Dawood Al Ruwaimi et al. — 2024-12-01

Severe acute pancreatitis (SAP) remains a challenging condition with significant morbidity and mortality despite advancements in medical and surgical care. Current treatment strategies are multifactorial, involving supportive care, nutritional management, infection control, and surgical intervention when indicated. However, there is still an ongoing debate regarding optimal approaches, including the timing of interventions, use of antibiotics, and the role of minimally invasive procedures. This review highlights recent evidence and controversies in the management of SAP, focusing on the efficacy and timing of treatment modalities to improve patient outcomes.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/283
https://doi.org/10.5281/zenodo.14502518

The Effect of Spiritual Self-Care Training on the Feeling of Comfort in Hospitalized Women: A Comprehensive Review

Munayfah Salamah Alanazi et al. — 2024-12-01

Spiritual self-care plays a vital role in promoting emotional well-being and enhancing comfort, particularly for hospitalized women facing physical and psychological challenges. This review explores the impact of spiritual self-care training on the comfort levels of women in healthcare settings. Emphasis is placed on the mechanisms through which spiritual practices contribute to overall well-being, recent studies evaluating intervention effectiveness, and recommendations for integrating spiritual care into clinical practice.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/273
https://doi.org/10.5281/zenodo.14480519

The Influence of Gender Role and Women’s Empowerment on Couples’ Fertility Experiences: A Comprehensive Review

Mashael Ayesh Bumozah et al. — 2024-12-01

Abstract

Gender roles and women’s empowerment play a pivotal role in shaping couples’ fertility experiences, including decision-making, family size, and reproductive health outcomes. Traditional gender norms often place women in subordinate positions, influencing their ability to make autonomous reproductive choices. Women’s empowerment—defined as access to education, employment, decision-making power, and healthcare—has emerged as a critical factor for fertility preferences and family planning. This review explores how gender roles and women’s empowerment intersect to impact fertility experiences and provides evidence from recent studies on their outcomes.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024
Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/281
https://doi.org/10.5281/zenodo.14497919

Impact of Health Practitioners on Mental Health: A Comprehensive Review

Saleh Radhi A et al. — 2024-12-01

Mental health is a critical component of overall well-being, and health practitioners play a pivotal role in its promotion, prevention, diagnosis, and treatment. This review explores the multifaceted impact of health practitioners on mental health, focusing on their roles in providing care, reducing stigma, and enhancing accessibility to mental health services. Furthermore, it highlights the challenges practitioners face, including inadequate training, resource constraints, and high levels of burnout. Emerging evidence underscores the effectiveness of practitioner-led interventions in improving mental health outcomes, particularly when employing multidisciplinary and culturally sensitive approaches. This review aims to provide insights into the contributions and challenges faced by health practitioners in the mental health domain, offering recommendations for improving their impact.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/271
https://doi.org/10.5281/zenodo.14480307

Towards Digital Coaching: Opportunities , Personalization and Challenges

El Houcine El Bazi et al. — 2025-01-18

This study underscores the growing demand for digital coaching as a real response to evolving personal and market needs. This transformative shift has fostered a synergy between human intuition and technological innovation. This, in other words, reshape the future of coaching by unlocking new opportunities for growth and fulfilment for both coaches and coachees. Moreover, the flexibility by removing geographical barriers through online access to coaching materials and sessions reinforces hybrid model thatensures a personalised and comprehensive coaching experience. This, in return, attracts a broader user audience and contributing to the overall coaching market.

Relationship between Personality Characteristics and Sleep Quality in Menopausal Women: A Comprehensive Review

Radeah Mohammed Alnasser et al. — 2024-12-01

Menopause is a critical phase in a woman's life characterized by physiological, hormonal, and psychological changes that can significantly affect sleep quality. Personality traits, such as neuroticism, extraversion, and conscientiousness, play an essential role in determining how women cope with menopausal symptoms, including sleep disturbances. This review examines the relationship between personality characteristics and sleep quality in menopausal women, highlighting key findings from recent studies. Furthermore, the implications for targeted interventions to improve sleep quality are discussed.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/278
https://doi.org/10.5281/zenodo.14481061

Smoking Cessation in Saudi Arabia: A Comprehensive Review

Bayan Emad Alabbad et al. — 2024-12-01

Smoking remains a significant public health challenge in Saudi Arabia, with high prevalence rates among adults and young populations. Despite national efforts to curb smoking, such as awareness campaigns, taxation policies, and smoking cessation programs, the rates of success in quitting remain suboptimal. This review explores the current smoking cessation strategies in Saudi Arabia, the barriers to success, and recommendations for improving outcomes. Recent studies emphasize the need for culturally tailored interventions, improved healthcare provider training, and expanded use of pharmacotherapy and behavioral counseling.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/286
https://doi.org/10.5281/zenodo.14529221

The Relationship between Knowledge, Attitude, and Tendency to Care for HIV/AIDS Patients among Nurses and Midwives: A Comprehensive Review

Naif Khalid Alfarut et al. — 2024-12-01

HIV/AIDS remains a global health challenge requiring effective care and support from healthcare professionals, including nurses and midwives. The knowledge, attitudes, and willingness to provide care for patients living with HIV/AIDS significantly influence the quality of care provided. This review explores the relationship between knowledge, attitudes, and the tendency of nurses and midwives to care for HIV/AIDS patients. The findings highlight the critical role of education, training, and workplace policies in improving healthcare professionals' competence and willingness to care for these patients.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/276
https://doi.org/10.5281/zenodo.14480871

Gene Polymorphisms of TNF-238G/A, TNF-308G/A, IL10-1082G/A, TNFAIP3, and Comorbidity Occurrence: A Comprehensive Review

Azhar Ahmed Abualr et al. — 2024-12-01

Gene polymorphisms play a pivotal role in susceptibility to various diseases, including inflammatory and autoimmune disorders. Tumor Necrosis Factor-alpha (TNF-α) gene polymorphisms (-238G/A and -308G/A), interleukin-10 (IL-10) gene polymorphism (-1082G/A), and TNFAIP3 (TNF-α-induced protein 3) polymorphisms are associated with inflammatory pathways and immune responses. These genetic variations are implicated in the occurrence and severity of comorbidities such as cardiovascular diseases, metabolic syndrome, autoimmune disorders, and infections. This review highlights the association of these polymorphisms with comorbid disease development, providing an analysis of the genetic contributions to disease pathophysiology and clinical implications.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/284
https://doi.org/10.5281/zenodo.14510785

Application of Donabedian Quality-of-Care Framework to Assess the Outcomes of Medication Use in Pediatric ICU: A Review

Ali Mohammed Alhassan — 2024-12-01

The Donabedian quality-of-care framework offers a structured approach to evaluating healthcare quality, encompassing structure, process, and outcome domains. Medication use in the pediatric intensive care unit (PICU) requires special attention due to the high-risk environment and vulnerable population. This review explores the application of the Donabedian framework in assessing medication use in the PICU, focusing on structural factors such as staffing and technology, processes such as prescribing and administration, and outcomes such as adverse drug events and clinical efficacy. Recommendations for improving quality and patient safety are discussed.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/274
https://doi.org/10.5281/zenodo.14480610

Breast Cancer and Associated Risk Factors: A Comprehensive Review

Mohammed Ail Al Barak et al. — 2024-12-01

Breast cancer is the most common malignancy affecting women worldwide, with a rising incidence in both developed and developing countries. This review explores the associated risk factors for breast cancer, including genetic predisposition, lifestyle habits, hormonal influences, and environmental exposures. Understanding these risk factors is crucial for prevention, early detection, and targeted interventions. Recent studies have emphasized the role of modifiable risk factors such as diet, physical activity, and obesity alongside non-modifiable factors like age, family history, and genetic mutations.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/282
https://doi.org/10.5281/zenodo.14502506

Gene Editing for the Treatment of Alzheimer’s Disease: A Comprehensive Review

Haider Abdullah Alsanawi et al. — 2024-12-01

Abstract

Alzheimer’s disease (AD) is a progressive neurodegenerative condition characterized by cognitive impairment, memory loss, and significant functional decline. Current treatment strategies focus on symptom management but do not target the disease's underlying genetic and molecular causes. Gene editing, particularly the CRISPR-Cas9 system, has emerged as a transformative tool to modify genetic pathways implicated in AD, including those related to amyloid-beta accumulation, tau hyperphosphorylation, and apolipoprotein E (APOE) polymorphisms. This review discusses the potential applications of gene editing in AD treatment, preclinical advancements, challenges in implementation, and the ethical considerations surrounding this innovative therapeutic strategy.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/272
https://doi.org/10.5281/zenodo.14480412

The Effect of Mother’s Training via Newsletter and Group Discussion on the Energy Intake of Preschool Children: A Comprehensive Review

Aqeel Jawad Aljubarah et al. — 2024-12-01

Abstract

Maternal education is a key determinant in improving preschool children's dietary intake and overall nutritional status. This review explores the effect of mother-centered training interventions—delivered through newsletters and group discussions—on the energy intake of preschool-aged children. Evidence suggests that accessible education methods, such as newsletters and interactive group discussions, can positively influence mothers' nutritional knowledge and practices, leading to improved dietary energy intake in children. This review discusses recent findings, implementation strategies, and the potential impact of these approaches.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/280
https://doi.org/10.5281/zenodo.14497917

Toward the Digital Coaching: Personalization, Adaptation and Challenges

El Houcine El Bazi — 2024-12-01

With the arrival of the digital age, coaching, like other disciplines that focus on the human being, finds itself in a conjunctural break with its professional framework centred on well-being, empathy, direct dialogue and the immediate reactions and emotions of the client. The digital alternative to coaching, characterized by the use of online platforms, mobile applications, live chat, video calls and other digital resources, is advancing in a transcendental and fragmentary direction rather than an immanent one. In this work, we will explore the concept of digitalising life coaching in various situations such as during pandemics, in busy schedules, in remote areas, and with considerations of discretion and anonymity. We will begin by outlining, in a linear and progressive manner, the transition from the demythification of traditional face-to-face coaching to the personalisation of digital coaching. Secondly, we will list the advantages and disadvantages of digital alternative. Finally, we will present some illustrative statistics in order to clarify and specify our theme.

Received Date: November 05, 2024

Accepted Date: November 26, 2024

Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/305 https://doi.org/10.5281/zenodo.14611349

Epstein-Barr Virus: A Comprehensive Review

Abdullah Issa Alhabeeb et al. — 2024-12-01

Epstein-Barr Virus (EBV), a member of the herpesvirus family, infects more than 90% of the global population. This ubiquitous pathogen is associated with a range of clinical conditions, including infectious mononucleosis, autoimmune diseases, and malignancies such as Hodgkin’s lymphoma, Burkitt’s lymphoma, and nasopharyngeal carcinoma. This review explores the virology, transmission, clinical manifestations, diagnosis, and treatment options of EBV, emphasizing the mechanisms underlying its persistence and pathogenicity, as well as future directions for prevention and management.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/277
https://doi.org/10.5281/zenodo.14480957

Digital Coaching: Personalization, Adaptation and Challenges

El Houcine El Bazi — 2024-12-01

Key words: challenges, digitalisation, life coaching, personalization

Insulin Resistance: A Pathway to Metabolic Syndrome – A Comprehensive Review

Amnah abd majeed bujbarah et al. — 2024-12-01

Insulin resistance (IR) plays a pivotal role in the development of metabolic syndrome (MetS), a cluster of conditions that includes central obesity, dyslipidemia, hypertension, and hyperglycemia. The prevalence of insulin resistance and its connection to MetS is increasing globally, driven by sedentary lifestyles, poor dietary habits, and genetic predispositions. This review explores the underlying mechanisms linking insulin resistance to MetS, discusses its epidemiology, and examines current diagnostic tools and therapeutic approaches. Recent advancements in pharmacological and lifestyle interventions are also highlighted, along with areas for future research.

Received Date: November 06, 2024
Accepted Date: November 27, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/248
https://doi.org/10.5281/zenodo.14251157

Management of Diabetic Ketoacidosis: Core Role of Nurses – A Comprehensive Review

Samar Abdullah Bosana et al. — 2024-12-01

Diabetic ketoacidosis (DKA) is a life-threatening acute complication of diabetes mellitus characterized by hyperglycemia, ketonemia, and metabolic acidosis. Its management requires rapid intervention and a multidisciplinary approach, where nurses play a pivotal role. This review focuses on the pathophysiology, clinical management, and critical role of nursing in DKA care. It emphasizes the importance of monitoring, patient education, and early intervention to improve outcomes. The integration of evidence-based practices into nursing care for DKA is discussed, along with recommendations for training and protocols to enhance nursing performance.

Received Date: November 06, 2024
Accepted Date: November 27, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/249

https://doi.org/10.5281/zenodo.14251202

Enhancement of Medication Adherence: The Core Role of Nurses – A Comprehensive Review

Marwh Habib Alhubail et al. — 2024-12-01

Medication adherence is critical in managing acute and chronic diseases, reducing hospitalizations, and improving patient outcomes. Non-adherence is a persistent challenge that compromises treatment efficacy and increases healthcare costs. Nurses play a central role in enhancing medication adherence through patient education, motivational support, and systematic monitoring. This review explores the factors influencing medication adherence, strategies employed by nurses to improve compliance, and evidence-based practices in various healthcare settings. Recent advancements in technology and multidisciplinary approaches to support adherence are also discussed.

Received Date: November 06, 2024
Accepted Date: November 27, 2024
Published Date: December 01, 2024

https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/250

https://doi.org/10.5281/zenodo.14251233

Mobile Text and Call as Effective Tools to Reduce Sickle Cell Crises Hospitalization: A Comprehensive Review

Ali Hussain Albattat et al. — 2024-12-01

Sickle cell disease (SCD) is a chronic condition characterized by recurring painful crises and complications, leading to frequent hospitalizations and reduced quality of life. Effective management strategies are crucial to minimize hospital admissions and improve patient outcomes. This review explores the role of mobile text messaging and phone call interventions in enhancing patient care for SCD. These tools have shown promise in improving medication adherence, patient education, and self-management, reducing the frequency of crises and hospitalization rates. The integration of mobile health (mHealth) in SCD care provides a cost-effective and scalable approach to addressing the challenges faced by patients and healthcare providers.

Received Date: November 06, 2024
Accepted Date: November 27, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/251
https://doi.org/10.5281/zenodo.14251253

Psychological Therapies for Thalassemia: Current Strategies

Alaa Fouad Almubarak et al. — 2024-12-01

Thalassemia, a genetic blood disorder, presents significant physical and psychological challenges to patients due to its chronic nature and the demanding treatments required. Beyond medical management, the psychological burden associated with thalassemia, such as depression, anxiety, and reduced quality of life, necessitates tailored psychological interventions. This review explores current psychological therapy strategies employed to improve mental health outcomes for patients with thalassemia, including cognitive-behavioral therapy (CBT), family therapy, psychoeducation, and mindfulness-based approaches. The integration of these therapies alongside medical treatment is vital for holistic care and improved quality of life.

Received Date: November 06, 2024
Accepted Date: November 27, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/252
https://doi.org/10.5281/zenodo.14251274

Comprehensive Review of COIN Strategies for Patients with Cancer

Nasser Aqeel Nasser Alhajji et al. — 2024-12-01

Cancer care has evolved significantly with the introduction of COIN (Cancer Optimization and Integration Network) strategies that aim to improve outcomes for patients. These strategies focus on integrating multidisciplinary care, patient-centered approaches, and innovative technologies. COIN strategies prioritize personalized treatment plans, coordinated care, and the inclusion of mental health support to enhance quality of life and survival rates. This review examines the core components of COIN strategies in oncology, their benefits, challenges, and their potential impact on the holistic care of cancer patients.

Received Date: November 06, 2024
Accepted Date: November 27, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/253
https://doi.org/10.5281/zenodo.14251285

CAR-T Cell Therapy: Present and Future Perspectives – A Comprehensive Review

Mohammed Ahmed Aliassa et al. — 2024-12-01

Chimeric antigen receptor T-cell (CAR-T) therapy represents a breakthrough in cancer immunotherapy. By engineering T-cells to specifically target cancer cells, CAR-T therapy has demonstrated significant success in treating hematological malignancies such as acute lymphoblastic leukemia (ALL) and non-Hodgkin’s lymphoma. However, challenges like relapse, toxicity, and limited efficacy in solid tumors highlight the need for advancements in the field. This comprehensive review explores the current applications of CAR-T therapy, its limitations, and future directions aimed at optimizing this revolutionary treatment.

Received Date: November 06, 2024
Accepted Date: November 27, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/254
https://doi.org/10.5281/zenodo.14251301

Glioblastoma Treatment and Quality of Life in Children: A Review

Ahmed Ali Al Saleem et al. — 2024-12-01

Glioblastoma (GBM) is an aggressive and rare brain tumor in children, with significantly different biological and clinical features compared to adult GBM. Despite advances in treatment modalities, the prognosis for pediatric GBM remains poor, and the aggressive nature of therapies often impacts the quality of life (QoL) in affected children. This review discusses current treatment strategies, including surgery, radiotherapy, and chemotherapy, alongside emerging therapies such as immunotherapy and targeted approaches. Additionally, it evaluates the impact of these treatments on the quality of life, focusing on neurocognitive, emotional, and social aspects, and the importance of supportive care.

Received Date: November 06, 2024
Accepted Date: November 27, 2024
Published Date: December 01, 2024
Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/255
https://doi.org/10.5281/zenodo.14251321

Impact of Exercise on Type 2 Diabetes Mellitus: A Comprehensive Review

Rehab Abdullah Yahia et al. — 2024-12-01

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and hyperglycemia, often accompanied by obesity and cardiovascular complications. Lifestyle interventions, particularly exercise, have proven to be effective in managing T2DM by improving glycemic control, enhancing insulin sensitivity, and reducing cardiovascular risk factors. This review examines the impact of different types of exercise—such as aerobic, resistance, and high-intensity interval training (HIIT)—on glycemic control and metabolic health in individuals with T2DM. The review also explores the mechanisms underlying these benefits and discusses challenges in adherence and future directions for integrating exercise into diabetes care.

The Role of Artificial Intelligence in Surgical Procedures: A Comprehensive Review

Fatin Riyadh jawad alhoudar et al. — 2024-12-01

The application of artificial intelligence (AI) in surgery is revolutionizing the field of medicine, offering new possibilities for precision, efficiency, and patient outcomes. AI technologies, such as machine learning (ML), computer vision, and natural language processing, are now integral to various aspects of surgical practice, from preoperative planning and intraoperative navigation to postoperative care and training. This review explores the current and emerging roles of AI in surgical procedures, focusing on robotic-assisted surgery, image-guided interventions, predictive analytics, and personalized treatment approaches. It also addresses the challenges and ethical considerations associated with implementing AI in surgical practice.

Key words: Artificial intelligence , health care , surgery

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/257
https://doi.org/10.5281/zenodo.14254293

Genomics of Chronic Myeloid Leukemia (CML): Treatment Benefits and Future of Gene Therapy

Forat Jafar Ali Alkholeef et al. — 2024-12-01

Chronic Myeloid Leukemia (CML) is a hematological malignancy driven primarily by the BCR-ABL1 fusion gene, resulting from the translocation between chromosomes 9 and 22 (the Philadelphia chromosome). Advances in genomics have revolutionized CML management, with tyrosine kinase inhibitors (TKIs) offering remarkable clinical outcomes. This review explores the genomic underpinnings of CML, the benefits of current TKI-based treatments, and the potential role of gene therapy in shaping the future of personalized CML care. Emphasis is placed on novel gene-editing tools like CRISPR-Cas9 and their promise in eradicating leukemic stem cells and achieving treatment-free remission (TFR).

KEY WORDS: CHRONIC, ABL, CART CELL

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/258
https://doi.org/10.5281/zenodo.14254310

Childhood Acute Lymphoblastic Leukemia (ALL): Diagnosis, Treatment, and Management

Ahmed Hussain Almahdi et al. — 2024-12-01

Childhood Acute Lymphoblastic Leukemia (ALL) is the most common pediatric malignancy, accounting for approximately 25% of childhood cancers. With advancements in diagnostic tools, treatment protocols, and supportive care, survival rates for ALL have significantly improved, reaching nearly 90% in high-income countries. This review discusses the current approaches to diagnosing, treating, and managing childhood ALL, highlighting recent advancements in genomics, immunotherapy, and risk stratification strategies that continue to shape patient outcomes.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/259
https://doi.org/10.5281/zenodo.14260201

Gaucher Disease: A Comprehensive Review

Mokhtar Abdullah Alkhalaf et al. — 2024-12-01

Gaucher disease (GD) is a rare lysosomal storage disorder caused by mutations in the GBA1 gene, which encodes the enzyme glucocerebrosidase. This deficiency results in the accumulation of glucocerebroside in macrophages, leading to multi-organ involvement. GD manifests in three main types, each with distinct clinical features. Recent advancements in enzyme replacement therapy (ERT), substrate reduction therapy (SRT), and novel treatment strategies such as gene therapy have improved patient outcomes significantly. This review explores the pathophysiology, clinical manifestations, diagnostic approaches, treatment modalities, and future prospects for managing Gaucher disease.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/260
https://doi.org/10.5281/zenodo.14260224

Digital Transformation in Real Estate and Facilities Management: Exploring Télécommunications Solutions at NITDA

Musa Mustapha Babayo — 2024-12-01

The integration of telecommunication infrastructure in real estate and facilities management has become increasingly essential due to rapid urbanization and technological advancements. In Nigeria, real estate management faces significant challenges, including inefficiency in property valuation, facility maintenance, and sustainability practices. However, the potential for telecommunication technologies to improve these aspects remains largely underexplored, especially in the context of Nigeria's ongoing smart city development initiatives. Given the importance of these technologies, the need for this study arises to explore how telecommunication policies and infrastructure, driven by the National Information Technology Development Agency (NITDA), influence real estate practices and sustainability in Nigerian urban centers. This study aims to examine the relationship between telecommunication infrastructure integration and improvements in property management and sustainability within the Nigerian real estate sector, with a focus on Abuja and Algos as case studies. Data were collected from 360 NITDA staff members using structured questionnaires and analyzed through descriptive and inferential statistical methods, including regression and correlation analyses. The findings revealed a strong positive correlation (r = 0.78, p < 0.05) between the integration of telecommunication infrastructure and improvements in property management efficiency. Furthermore, regression analysis demonstrated that 62% of the variance in facility management efficiency was attributable to telecommunication-enabled solutions such as IoT and smart grid systems. These results highlight the critical role of ICT in enhancing the efficiency and sustainability of real estate management in Nigeria. In conclusion, the study underscores the importance of telecommunication infrastructure in driving smart city goals and sustainable real estate practices. It recommends increased investments in ICT, policy harmonization, and capacity-building programs for stakeholders in the real estate sector to fully leverage telecommunication technologies.

Key words: Telecommunication, Real Estate, Sustainability, NITDA, Smart Cities

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/261
https://doi.org/10.5281/zenodo.14260660

Technological Innovation In Insulin Delivery: A comprehensive Review of Emerging solutions for Diabetes Management

Ibrahim, O.M et al. — 2024-12-01

The bad and ugly part of metabolic fuel in human body is the health impairment termed Diabetes which is non-infectious silent killer that has subjected human galaxy to high morbidity and mortality. Synthetic insulin delivery methods for ameliorating the effect caused by diabetes remains in the fore-front of development geared towards miniaturizing and getting user-friendly approach in curbing the pain and penury associated with Diabetes. There is evolution over the years from the crude insulin delivery tools to present day technological advancement of delivery system that dispense insulin to the systemic circulation which mimic the natural and physiological potency in management of the glycemic level in real time. The future landscape is aimed towards providing an automated technological panacea that is cost effective, efficient in monitoring and maintenance of the physiological level of glucose in real time scenario.

Key words: Glucose metabolism, Insulin therapy, New Technology, Type 1 and Type 2 Diabetes.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/262
https://doi.org/10.5281/zenodo.14261032

Visceral Leishmaniasis: A Comprehensive Review

Wala Ahmed Al Nasser et al. — 2024-12-01

Visceral leishmaniasis (VL), also known as kala-azar, is a life-threatening parasitic disease caused by Leishmania donovani and Leishmania infantum. Transmitted through the bites of infected female Phlebotomus or Lutzomyia sandflies, VL predominantly affects individuals in tropical and subtropical regions, particularly in South Asia, East Africa, and South America. The disease presents with systemic symptoms such as prolonged fever, weight loss, hepatosplenomegaly, and pancytopenia. Untreated cases often result in death. This review explores the epidemiology, pathophysiology, clinical features, diagnostic approaches, treatment options, and prevention strategies for visceral leishmaniasis, with a focus on recent advancements and challenges in its management.

Key words: Leishmaniasis , therapy , leishmania.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/263
https://doi.org/10.5281/zenodo.14270442

Placental Malaria Diagnosis and Risk of Neonatal Anemia: A Comprehensive Review

Sukinah Abd rab Alhassan Alzoori et al. — 2024-12-01

Placental malaria (PM) is a significant complication of malaria during pregnancy, caused primarily by Plasmodium falciparum. This condition leads to sequestration of infected erythrocytes in the placenta, causing inflammation and reduced nutrient exchange, which can result in neonatal anemia, low birth weight, and adverse pregnancy outcomes. Diagnosing placental malaria remains challenging due to its asymptomatic nature in many cases. This review explores the diagnostic techniques for placental malaria, its pathophysiology, and the association between PM and neonatal anemia. It also examines current preventive and therapeutic strategies to mitigate these complications, referencing recent studies.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/264
https://doi.org/10.5281/zenodo.14270481

Mycetoma: Diagnosis and Future Treatment Strategies - A Comprehensive Review

Omaimah Abdullah Aldubian et al. — 2024-12-01

Mycetoma is a chronic, progressively destructive infectious disease caused by fungi (eumycetoma) or bacteria (actinomycetoma). It is endemic in tropical and subtropical regions, particularly in countries within the "mycetoma belt," including Sudan and India. The condition often leads to severe morbidity due to delayed diagnosis and limited treatment options, resulting in deformities and disabilities. This review provides an overview of the diagnostic methods, challenges, and promising future treatment strategies, including pharmacological advancements, immunotherapy, and preventive measures.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/266
https://doi.org/10.5281/zenodo.14270511

Brain Abscess: Surgical Removal and Quality of Life - A Comprehensive Review

Banin Yousef Abdulla Alhajji et al. — 2024-12-01

Brain abscess, a localized collection of pus within the brain parenchyma, is a rare but life-threatening condition. Advances in neurosurgical techniques, imaging modalities, and antibiotic therapy have significantly improved survival rates. However, the long-term impact on patients' quality of life (QoL) remains an area of concern due to potential neurological deficits, cognitive impairments, and psychological challenges. This review examines the surgical management of brain abscesses, its outcomes, and the subsequent impact on QoL, while highlighting areas for future research.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/267
https://doi.org/10.5281/zenodo.14270552

Septic Shock: Core Role of Staff Nurses – A Comprehensive Review

Fadel Nooh M Almatar et al. — 2024-12-01

Septic shock is a critical condition characterized by severe circulatory and metabolic abnormalities resulting from systemic infection. It is associated with high mortality rates and requires prompt and effective intervention. Nurses, as part of the frontline healthcare team, play a pivotal role in the management of septic shock through early recognition, rapid implementation of treatment protocols, patient monitoring, and interdisciplinary collaboration. This review provides a comprehensive overview of the core responsibilities of staff nurses in managing septic shock and highlights best practices, challenges, and opportunities for improvement.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/268
https://doi.org/10.5281/zenodo.14278549

Blood Pressure and Heart Rate-Related Ratios as Predictors of Cardiovascular Diseases: A Comprehensive Review

Abdulaziz Amin Al Baqshi et al. — 2024-12-01

Blood pressure (BP) and heart rate (HR) are vital parameters widely utilized in assessing cardiovascular health. Beyond these standalone measures, derived indices such as pulse pressure (PP), mean arterial pressure (MAP), and heart rate variability (HRV) offer significant insight into cardiovascular disease (CVD) risk. This comprehensive review examines the role of BP and HR-related ratios—such as systolic-to-diastolic BP ratio, HR-to-BP ratio, and HRV—in predicting the onset and progression of CVDs. The review highlights recent research findings, clinical implications, and future prospects for utilizing these parameters in preventive cardiology.

Received Date: November 05, 2024
Accepted Date: November 26, 2024
Published Date: December 01, 2024

Available Online at https://www.ijsrisjournal.com/index.php/ojsfiles/article/view/269
https://doi.org/10.5281/zenodo.14278574